Smoking status and SARS-CoV-2 infection severity among Lebanese adults: a cross-sectional study | BMC Infectious Diseases


  • Severe Acute Respiratory Syndrome (SARS) [Internet]. [cited 2022 Mar 29]. Available at: https://www.who.int/westernpacific/health-topics/severe-acute-respiratory-syndrome.

  • Zhu Z, Lian X, Su X, Wu W, Marraro GA, Zeng Y. From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses. resp. Res. 2020;21(1):224.

    CAS PubMed PubMed CentralGoogle Scholar

  • Bian J, Li Z. Angiotensin converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator. Acta Pharm Sin B. 2021;11(1):1-12.

    CAS PubMedGoogle Scholar

  • Ni W, Yang X, Yang D, Bao J, Li R, Xiao Y, et al. Role of angiotensin converting enzyme 2 (ACE2) in COVID-19. critical care. 2020;24(1):422.

    PubMed PubMed Headquarters Google Scholar

  • Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin Converting Enzyme 2 (ACE2) as a SARS-CoV-2 Receptor: Molecular Mechanisms and Potential Therapeutic Target. Intensive care medicine Med. 2020;46(4):586-90.

    CAS PubMed PubMed CentralGoogle Scholar

  • Jackson CB, Farzan M, Chen B, Choe H. Mechanisms of SARS-CoV-2 entry into cells. nat. Rev Mol Cell Biol 2022;23(1):3-20.

    CAS PubMedGoogle Scholar

  • Mallah SI, Ghorab OK, Al-Salmi S, Abdellatif OS, Tharmaratnam T, Iskandar MA, et al. COVID-19: Overcoming a Global Health Crisis. Ann Clin Microbiol Antimicrob. 2021;20(1):35.

    CAS PubMed PubMed CentralGoogle Scholar

  • Schlesinger S, Neuenschwander M, Lang A, Pafili K, Kuss O, Herder C, et al. Risk phenotypes of diabetes and association with COVID-19 severity and death: a living systematic review and meta-analysis. diabetology. 2021;64(7):1480-91.

    CAS PubMed PubMed CentralGoogle Scholar

  • B. Thakur, P. Dubey, J. Benitez, J. P. Torres, S. Reddy, N. Shokar et al. A systematic review and meta-analysis of geographic disparities in comorbidities and associated severity and mortality in individuals with COVID-19. Sci Rep. 2021;20(11):8562.

    Google Scholar

  • Semenzato L, Botton J, Drouin J, Cuenot F, Dray-Spira R, Weill A, et al. Chronic diseases, health problems and the risk of COVID-19-related hospitalization and hospital mortality during the first wave of the epidemic in France: a cohort study of 66 million people. The Lancet Regional Health-Europe [Internet]. September 1, 2021 [cited 2022 Mar 29];8th. Available at: https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00135-6/fulltext.

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  • Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical features of coronavirus disease 2019 in China. N Engl. J Med. 2020;382(18):1708-20.

    CAS PubMedGoogle Scholar

  • Cattaruzza MS, Zagà V, Gallus S, D’Argenio P, Gorini G. Tobacco smoking and the COVID-19 pandemic: old and new problems. A summary of the evidence from the scientific literature. Acta Biomed. 2020;91(2):106-12.

    PubMed PubMed Headquarters Google Scholar

  • Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020;75(7):1730-41.

    CAS PubMedGoogle Scholar

  • Simons D, Shahab L, Brown J, Perski O. The association of smoking status with SARS-CoV-2 infection, hospitalization and mortality from COVID-19: a living rapid evidence review using Bayesian meta-analyses (version 7). Seeks. 2021;116(6):1319-68.

    PubMedGoogle Scholar

  • Vallarta-Robledo JR, Sandoval JL, Baggio S, Salamun J, Jacquérioz F, Spechbach H, et al. Negative association between smoking and positive SARS-CoV-2 testing: results of a Swiss outpatient sample population. Public Health Front. 2021;9. https://doi.org/10.3389/fpubh.2021.731981.

  • Prinelli F, Bianchi F, Drago G, Ruggieri S, Sojic A, Jesuthasan N, et al. Association between smoking and SARS-CoV-2 infection: cross-sectional study of the internet-based survey EPICOVID19. JMIR Public Health Surveillance. 2021;7(4):e27091.

    PubMed PubMed Headquarters Google Scholar

  • Jiang C, Chen Q, Xie M. Smoking increases risk of infectious diseases: a narrative review. Tob Induc Dis. 2020;14(18):60.

    Google Scholar

  • Peng F, Lei S, Zhang Q, Zhong Y, Wu S. Smoking correlates with prognosis of patients with coronavirus disease 2019 (COVID-19): an observational study. front physiol. 2021;12:634842.

    PubMed PubMed Headquarters Google Scholar

  • Shastri MD, Shukla SD, Chong WC, Rajendra KC, Dua K, Patel RP, et al. Smoking and COVID-19: what we know so far. Respiration Med. 2021;176:106237.

    PubMedGoogle Scholar

  • Haddad C, BouMalhab S, Sacre H, Salameh P. Smoking and COVID-19: a scoping review. Tob Use Insights. 2021;14:1179173X21994612.

    PubMed PubMed Headquarters Google Scholar

  • Zamorano Cuervo N, Grandvaux N. ACE2: Evidence of the role as an entry receptor for SARS-CoV-2 and implications for comorbidities. elf. 2021;9:e61390.

    Google Scholar

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  • Gadanec LK, McSweeney KR, Qaradakhi T, Ali B, Zulli A, Apostolopoulos V. Can the SARS-CoV-2 virus use multiple receptors to enter host cells? international J. Mol. Sci. 2021;22(3):992.

    CAS PubMed PubMed CentralGoogle Scholar

  • Dormoy V, Perotin JM, Gosset P, Maskos U, Polette M, Deslée G. Nicotinic receptors as SARS-CoV-2 spike co-receptors? Mean hypotheses. 2022;158:110741.

    CAS PubMedGoogle Scholar

  • Duszynski TJ, Fadel W, Wools-Kaloustian KK, Dixon BE, Yiannoutsos C, Halverson PK, et al. Association of health status and nicotine use with SARS-CoV-2 positivity rates. BMC Public Health. 2021;3(21):1786.

    Google Scholar

  • Ismail N, Hassan N, Abd Hamid MHN, Yusoff UN, Khamal NR, Omar MA, et al. Association of smoking and severity of COVID-19 infection in 5,889 patients in Malaysia: a multicenter observational study. Int J Infect Dis. 2022;1(116):189-96.

    Google Scholar

  • He Y, Sun J, Ding X, Wang Q. Mechanisms by which smoking increases risk of COVID-19 infection: a narrative review. Iran J Public Health. 2021;50(3):431-7.

    PubMed PubMed Headquarters Google Scholar

  • Wark PAB, Pathinayake PS, Kaiko G, Nichol K, Ali A, Chen L, et al. ACE2 expression is increased in airway epithelial cells from elderly and healthy males but decreased in asthma. respirology. 2021. https://doi.org/10.1111/resp.14003.

    PubMed PubMed Headquarters Google Scholar

  • Smith JC, Sausville EL, Girish V, Yuan ML, Vasudevan A, John KM, et al. Exposure to cigarette smoke and inflammatory signals increase expression of the SARS-CoV-2 receptor ACE2 in the airways. developer cell. 2020;53(5):514-529.e3.

    CAS PubMed PubMed CentralGoogle Scholar

  • Vardavas CI, Nikitara K. COVID-19 and smoking: a systematic review of the evidence. Tob Induc Dis. 2020;20(18):20.

    Google Scholar

  • Abdulrahim S, Jawad M. Socioeconomic disparities in smoking in Jordan, Lebanon, Syria and Palestine: a cross-sectional analysis of national surveys. Plus one. 2018;13(1):e0189829.

    PubMed PubMed Headquarters Google Scholar

  • Prevalence of current tobacco use (% of adults) – Lebanon | Data [Internet]. [cited 2022 Apr 6]. Available at: https://data.worldbank.org/indicator/SH.PRV.SMOK?locations=LB.

  • Nakkash R, Khader Y, Chalak A, Abla R, Abu-Rmeileh NME, Mostafa A, et al. Prevalence of cigarette and hookah tobacco smoking among adults in three Eastern Mediterranean countries: a cross-sectional household survey. BMJ open. 2022;12(3):e055201.

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    PubMed PubMed Headquarters Google Scholar

  • Khalil A, Dhingra R, Al-Mulki J, Hassoun M, Alexis N. Questioning the gender differences in the association of smoking with in-hospital survival of COVID-19 patients. Plus one. 2021;16(8):e0255692.

    CAS PubMed PubMed CentralGoogle Scholar

  • Baddoura R, Wehbeh-Chidiac C. Prevalence of tobacco use in the Lebanese adult population. Eastern Mediterranean Health J. 2001;7(4-5):819-28.

    CAS Google Scholar

  • Central administration of the statistics population [Internet]. [cited 2021 Nov 10]. Available at: http://www.cas.gov.lb/index.php/demographic-and-social-en/population-en.

  • Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, Wedderburn LR, et al. Male gender identified by global COVID-19 meta-analysis as a risk factor for death and ITU inclusion. Nat Commun. 2020;11(1):6317.

    CAS PubMed PubMed CentralGoogle Scholar

  • Capuano A, Rossi F, Paolisso G. COVID-19 kills more men than women: an overview of possible reasons. Cardiovascular Med. 2020;17(7):131.

    Google Scholar

  • Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, et al. Gender differences in patients with COVID-19: focus on severity and mortality. Public Health Front. 2020. https://doi.org/10.3389/fpubh.2020.00152.

    PubMed PubMed Headquarters Google Scholar

  • Townsend EA, Miller VM, Prakash YS. Sex differences and sex steroids in lung health and disease. Endocr Rev. 2012;33(1):1-47.

    CAS PubMed PubMed CentralGoogle Scholar

  • Camp PG, Coxson HO, Levy RD, Pillai SG, Anderson W, Vestbo J, et al. Gender differences in emphysema and respiratory disease in smokers. Chest. 2009;136(6):1480-8.

    PubMedGoogle Scholar

  • Haghani A, Arpawong TE, Kim JK, Lewinger JP, Finch CE, Crimmins E. Female susceptibility to the health effects of smoking in the elderly. Plus one. 2020;15(6):e0234015.

    CAS PubMed PubMed CentralGoogle Scholar

  • The AB. The Lung Diseases Network highlights the impact of comorbidity on SARS-CoV-2 infection and drug repurposing opportunities. BMC Med Genomics. 2021;17(14):226.

    Google Scholar

  • Lallai V, Manca L, Fowler CD. E-cigarette vape and pulmonary ACE2 expression: implications for coronavirus susceptibility. Environ Toxicol Pharmacol. 2021;1(86): 103656.

    Google Scholar

  • WHO statement: Tobacco use and COVID-19 [Internet]. [cited 2022 Apr 6]. Available at: https://www.who.int/news/item/11-05-2020-who-statement-tobacco-use-and-covid-19.



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